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Tadarise Black 80 mg is usually taken about 30 to 60 minutes before sexual activity with water. Unlike some ED medicines, tadalafil has a long duration of action, which may last up to 24–36 hours in many users. Sexual stimulation is required for the medicine to work, as it does not cause an erection on its own. It should not be taken more than once in 24–36 hours, depending on a doctor’s advice. Common side effects include headache, flushing, dizziness, nasal congestion, indigestion, back pain, and muscle aches. These effects are usually temporary and mild.